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Use of ondansetron during the first trimester of pregnancy can increase the risk of birth defects. If you become pregnant while taking this medication, contact Ondansetron has been found to be the most commonly used prescription oral antiemetic in pregnancy in the United States and was ranked as the fifth most commonly taken oral medication in pregnancy overall in the Slone Epidemiologic Center Birth Defects Study. 5 Ondansetron has been shown to have fewer side effects with less sedation 6 and You can take Zofran throughout your pregnancy until delivery, Newman says. But for most people, nausea and vomiting symptoms calm down by the time the first trimester comes to a close. Alternatives to Zofran in Pregnancy humatin generic Does taking ondansetron in pregnancy affect future behavior or learning for the child? One study looked at 78 infants who were exposed to ondansetron at any time during pregnancy. When examined between 7 days to 2 months of age, there were no unusual behaviors reported. In pregnancy it is used as third line medication. This means that it is used if two other medications have not helped with the woman’s symptoms. Ondansetron (Zofran ) – MotherToBaby Does taking ondansetron in pregnancy increase the chance of other pregnancy-related problems? Studies did not find a higher chance of pregnancy loss, preterm delivery (delivery before 37 weeks of pregnancy), or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth) when ondansetron was used during pregnancy.

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